Argatroban and Pregnancy

In many cases, the benefits of using argatroban during pregnancy clearly outweigh the risks. During animal studies, this drug did not appear to cause any problems in the fetus. Therefore, the FDA has classified it as a pregnancy Category B drug, meaning it is probably safe for use in pregnant women.

Can Pregnant Women Receive Argatroban?

Argatroban is an anticoagulant ("blood thinner") used for people who cannot take heparin or heparin-like medications due to a condition known as heparin-induced thrombocytopenia (HIT). Based on the results of animal studies, argatroban is probably safe for use during pregnancy.

What Is Pregnancy Category B?

Argatroban is classified as a pregnancy Category B drug. The U.S. Food and Drug Administration (FDA) uses a pregnancy category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy.
Pregnancy Category B is given to medicines that have not been adequately studied in pregnant humans but do not appear to cause fetal harm in animal studies. Medications that have been shown to be safe for use in pregnancy in humans but have caused problems in laboratory animals are also given a Category B rating.
In studies of pregnant animals, argatroban was not shown to cause any problems. However, it is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category B medicine should be given to a pregnant woman only if her healthcare provider believes that the benefits to the woman outweigh any possible risks to her unborn child.
In most situations, the need for argatroban outweighs the potential risks, as the drug can be life-saving.

Final Thoughts

In many cases, the benefits of using argatroban during pregnancy clearly outweigh the possible risks. In any case, women should discuss the possible risks and benefits for their own particular situation with their own healthcare provider(s).
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Argatroban Medication Information

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