Fragmin Uses

Fragmin After Cardiac Events
Fragmin is also approved to prevent complications after certain "cardiac events" (the medical term for various heart-related occurrences). In particular, Fragmin (when combined with aspirin) has been shown to reduce the risk of death, heart attacks, or recurrent angina (chest pain) in people who have recently had a bout of unstable angina or non-Q-wave myocardial infarction. Unstable angina is a type of chest pain that often signals that a heart attack is imminent, and non-Q-wave myocardial infarction is a type of mild heart attack.

How Does It Work?

Fragmin is a low-molecular-weight heparin medication. Like heparin, Fragmin works to prevent the formation of clots (or the growth of existing clots) by binding to an enzyme in the body known as antithrombin III. In doing so, Fragmin accelerates the activity of antithrombin III.
Because antithrombin III inhibits two clotting factors (known as factor Xa and IIa), Fragmin effectively inhibits these two clotting factors as well. This action helps to reduce clot formation.
Like other "blood thinners," Fragmin does not break down clots. Instead, it slows down clot formation, giving the body a chance to naturally break down the clots.

Can Children Use It?

Fragmin is not approved for use in children. This does not mean that children absolutely cannot use Fragmin; it just means that this medication (like most medications) has not been adequately studied in children. Talk with your child's healthcare provider about the particular benefits and risks of using Fragmin in children.

Off-Label Uses for Fragmin

On occasion, your healthcare provider may recommend Fragmin for something other than the uses discussed in this article. Some these possible "off-label" uses of Fragmin include:
  • "Bridge therapy" in people who must temporarily stop taking warfarin (Coumadin®, Jantoven®)
  • Treating blood clots in people without cancer
  • Long-term management of clotting disorders in people who cannot take warfarin (and who do not have cancer)
  • Preventing DVT after moderate-risk general surgeries
  • Preventing DVT after knee replacement surgery
  • Preventing DVT after gynecological surgery
  • Preventing initial DVT in people with cancer
  • Managing clotting disorders in pregnant women or preventing recurring pregnancy loss (see Fragmin and Pregnancy).
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Fragmin Medication Information

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