Hemophilia Treatment

Hemophilia Treatment: Sources of Clotting Factors

The clotting factor concentrates that are used in replacement therapy come from two sources:
  • Blood from human donors
  • Lab-produced clotting factors called "recombinant" factors, which are not made from human blood.
Clotting factors from either source are generally considered safe. However, recombinant factors cannot carry viruses and are usually preferred for treating hemophilia. Recombinant clotting factors work the same as natural clotting factors.
Infusions need to be given once daily or more frequently when treatment has begun because half of the activity of factor 8 is gone in 8 to 12 hours and half of the activity of factor 9 is gone in 12 to 24 hours.
Clotting factors used in replacement therapy today are powerful and easy to store, mix, and use at home.
(Click Hemophilia Recombinant Factors to learn more about this therapeutic option.)

Hemophilia Treatment: Replacement Therapy to Prevent Bleeding

Some people may receive replacement therapy on a regular basis to prevent bleeding. The goal of replacement therapy is to keep the levels of clotting factors in the blood high enough so that bleeding will not occur. This hemophilia treatment is more likely to be used in people with severe cases, and it is often used in children to prevent damage to joints from bleeding.
Preventive replacement therapy can be given on a:
  • Long-term basis, usually two to three times a week
  • Shorter-term basis, usually every few months
  • Short-term basis, usually before participating in an activity that could cause bleeding.
Preventive therapy can be intensive and expensive, and it is often given at home.

Hemophilia Disease

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