Innohep and Pregnancy

Although Innohep (tinzaparin sodium) has a pregnancy Category B rating, more suitable drugs are available for women who are expecting. This is because Innohep contains benzyl alcohol, a preservative that could cause serious problems in a premature infant. Since other similar medications (Lovenox and Fragmin single-dose syringes) do not contain this preservative, they are generally preferred for use during pregnancy.

I'm Pregnant -- Can I Use Innohep?

Innohep® (tinzaparin sodium) is a prescription medication approved to treat deep vein thrombosis (DVT) blood clots. Although the medication itself is generally thought to be safe for use during pregnancy, a preservative used in Innohep may not be safe.

What Is Pregnancy Category B?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category B is given to medicines that have not been adequately studied in pregnant humans but do not appear to cause harm to the fetus in animal studies.
In addition, medications that have been shown to be safe for use in pregnancy in humans but have caused problems in laboratory animals are also given a pregnancy Category B rating.
Innohep is thought to be safe for use during pregnancy for several reasons. In animal studies, the drug did not increase the risk of birth defects. Also, Innohep does not cross the placenta to the developing fetus, so it is not expected to increase the risk of bleeding in the fetus.
Finally, a few small studies that looked at the use of Innohep in pregnant women generally show that the drug does not appear to cause any significant problems, other than the usual risks with Innohep that may apply to any individual.
However, it should be noted that there are more suitable low-molecular-weight heparin medications for pregnant women, since Innohep contains benzyl alcohol as a preservative. Benzyl alcohol crosses the placenta and can cause serious problems in premature newborns. Lovenox® and Fragmin® single-dose syringes are better options since they contain no benzyl alcohol and are similar to Innohep.
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Innohep Medication Information

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