Innohep Warnings and Precautions

Specific Precautions and Warnings With Innohep

Warnings and precautions to be aware of prior to using Innohep include the following:
  • As with all "blood thinners," one of the most serious side effects of Innohep is internal bleeding, which can be fatal. Let your healthcare provider know if you develop any signs of bleeding, such as:
    • Easy bruising
    • Cuts or scrapes that are slow to stop bleeding
    • Black, tarry stools; bright-red blood in the stool; or vomiting of blood (signs of gastrointestinal bleeding)
    • Signs of bleeding in the brain, such as vision or speech changes, weakness or numbness in an arm or leg, or a severe headache.
  • There have been reports of spinal or epidural hematoma in people who had spinal, epidural, or caudal anesthesia, or spinal punctures, while on Innohep. This is a serious problem that can sometimes cause long-term or permanent paralysis. Each case must be evaluated on an individual basis, but you may not be a candidate for these types of anesthesia or procedures if you are on Innohep.
  • Make sure your healthcare provider knows if you have kidney disease, diabetic retinopathy, uncontrolled high blood pressure, recent ulcers of the digestive tract, or any obvious bleeding. Extra care must be taken in such situations.
  • This drug should be used with extreme caution in people with bacterial endocarditis; bleeding disorders that increase the risk of bleeding; active stomach or intestinal ulcers; bleeding in the brain; or who have recently had brain, spinal, or eye surgery.
  • Innohep may interact with a number of other medications (see Innohep Drug Interactions for more information).
  • As with other heparin-like drugs, Innohep can cause low blood platelets (thrombocytopenia). In many cases, this is mild and causes no other problems. In rare cases, however, a severe reaction known as heparin-induced thrombocytopenia (HIT) may occur. This dangerous problem can cause excessive clotting, loss of limbs, and even death.
  • There have been rare reports of priapism (a painful penile erection that does not go away) in people using Innohep. If you develop this problem, you must seek immediate medical attention, as untreated priapism can cause permanent damage.
  • It is not known if this medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to beginning treatment (see Innohep and Breastfeeding).
  • Innohep is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are currently unknown (see Innohep and Pregnancy).
However, Innohep contains benzyl alcohol, a preservative that can be dangerous to premature newborns. Because benzyl alcohol may cross the placenta, pregnant women should generally avoid this medication.
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Innohep Medication Information

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