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Argatroban Interactions ExplainedOther medications that have anticoagulant, antiplatelet, or thrombolytic effects may increase the risk of bleeding with argatroban. Always check with your healthcare provider before combining argatroban with any such medications, even nonprescription ones. In some cases, these medications are combined on purpose.
For instance, when people are switched from argatroban to warfarin, there is usually a period of overlap when both medications should be used because it takes awhile for warfarin to start working. Your healthcare provider should account for this interaction and should provide close monitoring.
Additional Information and Notable ExceptionsArgatroban does not interact with vitamin K or foods rich in vitamin K. People sometimes mistakenly assume that it does, as warfarin (Coumadin, Jantoven), an oral anticoagulant, interacts with vitamin K.
Argatroban does not react with acetaminophen (Tylenol®). Therefore, acetaminophen is usually the preferred over-the-counter (OTC) pain or fever medication for people receiving argatroban.