Available by prescription, Fragmin is a drug licensed to prevent blood clots in people with certain conditions. This medication comes in the form of an injection and is administered just under the skin once or twice daily. It works by slowing down clot formation, allowing the body to naturally break down the clots. Potential side effects may include bleeding, bruising, and pain at the injection site.
What Is Fragmin?
Fragmin® (dalteparin sodium) is a prescription medication approved to prevent blood clots in certain situations. It may also be used specifically for the treatment of blood clots in people with cancer (but not in people without cancer). It is also approved to prevent complications in people who have recently had a heart attack or unstable angina (a type of chest pain that may indicate a heart attack is imminent). Fragmin is taken by injection just below the skin.
Fragmin is manufactured by Pfizer Inc., for Eisai, Inc.
How Does Fragmin Work?
Fragmin is a low-molecular-weight heparin medication. Like heparin, Fragmin works to prevent the formation of clots (or the growth of existing clots) by binding to an enzyme in the body known as antithrombin III. In doing so, Fragmin accelerates the activity of antithrombin III.
Because antithrombin III inhibits two clotting factors (known as factor Xa and IIa), Fragmin effectively inhibits these two clotting factors as well. This action helps to reduce clot formation.
Like other "blood thinners," Fragmin does not break down clots. Instead, it slows down clot formation, giving the body a chance to naturally break down the clots.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Fragmin [package insert]. Woodcliff Lake, NJ: Eisai, Inc.;2009 December.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed May 5, 2010.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed May 5, 2010.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind.
Site users seeking medical advice about their specific situation should consult with their own physician. Click