Blood Home > Difference Between Coumadin and Lovenox

Although both medications are blood thinners, there are important differences between Coumadin and Lovenox (enoxaparin). Coumadin is an oral medication that is fairly inexpensive, while Lovenox comes in the form of an injection and is much more expensive. Also, there are no dietary restrictions when using Lovenox, as opposed to using Coumadin. In addition, Lovenox is much less subject to drug interactions.

Coumadin Versus Lovenox: An Overview

Lovenox® (enoxaparin sodium) and Coumadin® (warfarin sodium) are both prescription anticoagulant medications, commonly known as "blood thinners." However, there are some very important differences between Coumadin and Lovenox.

Basic Differences Between Lovenox and Coumadin

The most obvious difference between the two drugs is that Coumadin is taken by mouth, while Lovenox must be administered by subcutaneous injection (an injection just under the skin, much like insulin is injected). The second most obvious difference is that Lovenox is much more expensive than Coumadin (on a dose-per-dose basis).
Another basic difference between the two drugs is that Coumadin should be avoided during pregnancy, while Lovenox is considered safe for use during pregnancy (see Coumadin and Pregnancy and Lovenox and Pregnancy for more information).

Dietary and Drug Interaction Differences

Coumadin and Lovenox work in completely different ways. Coumadin is a vitamin K antagonist, while Lovenox is a low molecular weight heparin. Because Lovenox is not a vitamin K antagonist, there are no dietary restrictions (or food interactions) for Lovenox.
While both medications may interact with other drugs that affect blood clotting and bleeding, Coumadin is one of the most "interactive" drugs currently in use today -- meaning that it interacts significantly with a very large number of drugs. Lovenox is much less subject to drug interactions.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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