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Though most people tolerate Nascobal well, some of the common side effects reported with this drug include nausea, weakness, and headaches. Fortunately, most of the reactions to this nasal spray tend to be minor and easy to treat. However, seek immediate medical treatment if you develop potentially serious problems, such as fever, anxiety, or a swollen or painful tongue.

An Introduction to Nascobal Side Effects

Just like any medicine, Nascobal® (cyanocobalamin nasal spray) can cause side effects. However, not everyone who uses the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Nascobal. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Nascobal

Nascobal has been studied thoroughly in a clinical trial. In this study, the side effects that occurred in people using Nascobal were carefully documented and compared to the reactions that occurred in a similar group of people given intramuscular (an injection into a muscle) vitamin B12. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the other medicine.
Based on this clinical study, common Nascobal side effects included:
  • Infections, including a sore throat and the common cold -- in up to 12.5 percent of people
  • Nausea -- up to 4.2 percent
  • Weakness and lack of energy -- up to 4.2 percent
  • Headache -- up to 4.2 percent
  • Stuffy or runny nose -- up to 4.2 percent
  • Tongue swelling (glossitis) -- up to 4.2 percent
  • Abnormal sensations of tingling, burning, pricking, or numbness of the skin -- up to 4.2 percent.
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Last reviewed by: Kristi Monson, PharmD;
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