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People who have peripheral T-cell lymphoma may receive pralatrexate if their cancer has come back or has not responded to other treatments. This prescription medicine works by disrupting the multiplication process of the cancer cells. Side effects may include abnormal bruising, mouth sores, and nausea. This product is given as an intravenous injection once a week for six weeks, followed by a one-week break.

What Is Pralatrexate?

Pralatrexate (Folotyn®) is a prescription medication approved to treat peripheral T-cell lymphoma, a cancer that begins in the cells of the immune system. It is for use in people whose disease has not improved, or has returned after other treatment.
(Click What Is Pralatrexate Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any chemotherapy medicine, pralatrexate can cause side effects, some of which can be quite significant. Talk with your healthcare provider about ways to prevent or lessen side effects.
Common reactions to this chemotherapy drug include but are not limited to:
  • Mouth sores
  • Low platelet counts, which could cause abnormal bruising or bleeding
  • Nausea
  • Fatigue.
(Click Pralatrexate Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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