Pralatrexate works by inhibiting an enzyme known as dihydrofolate reductase. This enzyme is important for transforming an inactive form of folic acid into the active form, which is necessary to make some of the building blocks needed for DNA production. By inhibiting this enzyme, pralatrexate interferes with the ability of cells, including cancer cells, to repair and replicate (copy) themselves.
Can Children Use Pralatrexate?
Pralatrexate has not been adequately studied in children, and is not approved for use in this age group (usually defined as individuals younger than 18 years old). Talk to your child's healthcare provider about the risks and benefits of using this medication in children.
Is It Safe for Older Adults?
In clinical trials, people age 65 and older responded no differently to pralatrexate than those younger than this. However, some older adults may be more sensitive to the effects of this medication and may need to be monitored more closely during treatment.
What About Off-Label Pralatrexate Uses?
On occasion, a healthcare provider may recommend this medication for treating something other than peripheral T-cell lymphoma. This is called an "off-label" use. Possible off-label uses for pralatrexate may include treating other types of lymphoma, such as cutaneous T-cell lymphoma.
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