Blood Home > Rivaroxaban Dosage

Your dose of rivaroxaban will be determined based on factors such as why you are taking it and whether you are taking any other medications that may interact with it. For example, the standard amount in people who have had surgery is 10 mg taken once daily for 12 days (in people who had a knee replacement) or 35 days (for those who had a hip replacement).

An Introduction to Your Dosage of Rivaroxaban

The dose of rivaroxaban (Xarelto®) your healthcare provider recommends will vary, depending on several factors, such as:
  • The reason you are taking rivaroxaban
  • The type of surgery you had (for use after surgery)
  • Whether you are taking any medications that could interact with Xarelto
  • How well your kidneys are functioning.


As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.


Standard Rivaroxaban Dosing After Surgery

The standard rivaroxaban dose for preventing blood clots in people undergoing knee replacement or hip replacement surgery is 10 mg once daily. The first dose is given at least 6 to 10 hours after surgery, once all bleeding is under control. The drug is usually continued for 12 days (for knees) or for 35 days (for hips). At this low dosage, you can take the medication with or without food.

Standard Rivaroxaban Dosage for Atrial Fibrillation

The standard rivaroxaban dose for preventing blood clots and strokes in people with atrial fibrillation is 20 mg once daily with the evening meal. If your kidneys are not functioning as well as they normally should, a lower dosage (15 mg once daily with the evening meal) may be recommended. If you have severe kidney problems, this drug may not be appropriate for you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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