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When and How to Take Rivaroxaban

Some general considerations to keep in mind during treatment with rivaroxaban include the following:
  • For use after surgery, this medication is taken by mouth just once a day for a certain period of time after surgery (12 to 35 days, depending on the type of surgery). If you are taking the standard dose of 10 mg daily, you may take this medication with or without food. If you are taking the higher dosage (15 or 20 mg daily), you must take it with food.


  • For use in people with atrial fibrillation, this medication is taken once a day, with the evening meal, on an ongoing basis.
  • For treating existing blood clots (while preventing future blood clots at the same time), the drug is taken twice a day initially (with food), then switched to once a day (with food). The length of treatment will be determined by your healthcare provider, depending on your risk factors for future clots.


  • Try to take rivaroxaban at the same time each day to keep an even level of the drug in your bloodstream.
  • If you have trouble swallowing medications, the 15- and 20-mg rivaroxaban tablets may be crushed. The tablet should be crushed and mixed with applesauce immediately before you take your dose. The crushed tablets may also be mixed with water when given through a feeding tube. You will still need to eat after taking your dose in this manner. The 10-mg tablets should be swallowed whole.


  • For this drug to work properly, it must be taken as prescribed. You may be increasing your risk for serious problems if you stop taking it too soon.

Storage Information

Rivaroxaban should be stored at room temperature. Make sure to keep this and all other medications out of the reach of children and pets.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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