Nascobal Drug Interactions

Colchicine
Long-term use of colchicine may interfere with the absorption of vitamin B12 from the gastrointestinal (GI) tract. Although this would not directly react with Nascobal, as Nascobal is sprayed into the nostril, it could decrease the effectiveness of Nascobal by worsening your vitamin B12 deficiency. Talk to your healthcare provider about this potential interaction if you take colchicine.
 
Folic Acid
Folic acid can mask vitamin B12 deficiency. This means it will be more difficult for your healthcare provider to determine if you have a B12 deficiency from simple blood tests. If you are using Nascobal, do not take folic acid unless your healthcare provider recommends it.
 
Methotrexate
Although it does not directly interfere with Nascobal, methotrexate can interfere with the results of vitamin B12 and folic acid blood tests. These tests are used to monitor your response to Nascobal treatment.
 
Para-Aminosalicylic Acid
Para-aminosalicylic acid may interfere with the absorption of vitamin B12 from the gastrointestinal (GI) tract. Although this would not directly interact with Nascobal, as Nascobal is sprayed into the nostril, it could decrease the effectiveness of Nascobal by worsening your vitamin B12 deficiency. Talk to your healthcare provider about this potential interaction if you take para-aminosalicylic acid.
 
Pyrimethamine
Although it does not directly interfere with Nascobal, pyrimethamine can interfere with the results of vitamin B12 and folic acid blood tests, which are used to assess your response to Nascobal treatment.
 

Final Thoughts

It is possible that not all Nascobal drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.

Nascobal Medication Information

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