Pralatrexate and Cutaneous T-Cell Lymphoma

Available by prescription only, pralatrexate (Folotyn®) is specifically approved for use in the treatment of peripheral T-cell lymphoma in adults where the cancer has come back or has not responded adequately to other treatment.
However, there are also times when a healthcare provider may recommend this medication for treating another condition. This is called an "off-label" use. Possible off-label uses for pralatrexate may include the treatment of cutaneous T-cell lymphoma or other forms of lymphoma.
Pralatrexate works by inhibiting a certain enzyme that is necessary to make some of the building blocks needed for DNA production. By inhibiting this enzyme, the drug interferes with the ability of cells, including cancer cells, to multiply.
(Click What Is Pralatrexate Used For? for a more in-depth look at this topic, including information on how it works, whether it's safe for use in children, and off-label pralatrexate uses.)
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