Your healthcare provider will determine an appropriate pralatrexate dosage based primarily on your height and weight. The seven-week treatment course includes an intravenous (IV) injection given by your healthcare provider once a week for six weeks, followed by a one-week break. This cycle is repeated as long as the medication is effective and is not causing serious reactions.
An Introduction to Your Dosage of PralatrexateThe dose of pralatrexate (Folotyn®) your healthcare provider recommends will vary, based on a number of factors, including:
- Your height and weight
- How well you tolerate the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Pralatrexate Dosing GuidelinesPralatrexate is dosed based on body surface area, which is calculated using height and weight, and is expressed as milligrams per meters squared (mg per m2). The usual recommended dosage of pralatrexate for treating peripheral T-cell lymphoma is 30 mg per m2 given once a week for six weeks, followed by a one-week break. This seven-week cycle will repeat as long as the medicine is working and is not causing serious side effects.
Your healthcare provider will monitor you for potentially serious pralatrexate side effects throughout treatment. He or she may adjust your dose or recommend you skip a dose or stop treatment if you experience certain side effects, such as severe mouth sores or low blood cell counts.
You will need to take folic acid and vitamin B12 during treatment to help prevent certain potentially serious side effects. The usual folic acid dosage is 1 mg to 1.25 mg (1000 mcg to 1250 mcg) daily, starting 10 days before the first pralatrexate dose and continuing for at least 30 days after the last dose. The usual vitamin B12 dose is 1 mg injected into a muscle (an intramuscular, or IM, injection) starting no more than 10 weeks before the first pralatrexate dose and then every 8 to 10 weeks throughout treatment.