Important Information for Your Healthcare ProviderYou should talk with your healthcare provider prior to receiving this medication if you have:
- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Kidney disease, such as kidney failure
- Low blood cell counts, including low white blood cells or platelets
- An infection or get infections easily
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Folotyn and Pregnancy)
- Breastfeeding (see Folotyn and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Pralatrexate to learn more, including information on who should not receive the drug.)
How Does Pralatrexate Work?Pralatrexate works by inhibiting an enzyme known as dihydrofolate reductase. This enzyme is important for transforming an inactive form of folic acid into the active form, which is necessary to make some of the building blocks needed for DNA production. By inhibiting this enzyme, pralatrexate interferes with the ability of cells, including cancer cells, to repair and replicate (copy) themselves.