Drug Interactions With Pyridoxine

Certain medications may cause drug interactions with pyridoxine, including phenobarbital, phenytoin, and amiodarone. Early research suggests that pyridoxine may decrease the effectiveness of these medicines or increase the risk of sun sensitivity due to amiodarone. To minimize your risk of developing interactions, tell your healthcare provider about all other supplements and medications you are taking before using the vitamin.

An Introduction to Pyridoxine Drug Interactions

Pyridoxine (vitamin B6) can potentially interact with a few different medicines. Some of the medicines that may lead to pyridoxine drug interactions include:
 

Pyridoxine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when pyridoxine is combined with any of the drugs listed above.
 
Amiodarone
Some studies suggest that pyridoxine may increase the risk of sun sensitivity due to amiodarone, although other studies have not shown this effect. Be aware that you may be more sensitive to the sun. It is a good idea to use sunscreen if you will be out in the sun.
 
Phenobarbital
Early research suggests that pyridoxine may decrease the level of phenobarbital in the blood, perhaps making it less effective. If you take phenobarbital, do not start (or stop) taking high doses of pyridoxine without your healthcare provider's supervision.
 
Phenytoin
Early research suggests that pyridoxine may decrease the level of phenytoin in the blood, perhaps making it less effective. If you take phenytoin, do not start (or stop) taking high doses of pyridoxine without your healthcare provider's supervision.
 
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Pyridoxine (Vitamin B6) Information

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