Drug Interactions With Rivaroxaban

If heparin, aspirin, or certain other drugs are combined with rivaroxaban, negative interactions may occur. Taking these product together could decrease the effectiveness of certain medicines or increase your risk for bleeding. To help minimize your risk for these and other complications, tell your healthcare provider about all medications, supplements, and vitamins you are taking before starting treatment with this blood-thinning medicine.

An Overview of Rivaroxaban Interactions

Rivaroxaban (Xarelto®) may react with a number of other medications. Some of the drugs that can lead to interactions with rivaroxaban include but are not limited to:
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Medications that increase the risk of bleeding, such as:
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
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Written by/reviewed by: Kristi Monson, PharmD
Last reviewed by: Kristi Monson, PharmD
 
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