Drug Interactions With Rivaroxaban

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• CYP 3A4 inducer medications, such as:

• Aminoglutethimide (Cytadren^®)
• Bosentan (Tracleer^®)
• Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
• Dexamethasone (Decadron^®, Dexpak^®, Maxidex^®)
• Efavirenz (Sustiva^®)
• Efavirenz, emtricitabine, and tenofovir (Atripla^®)
• Etravirine (Intelence™)
• Fosphenytoin (Cerebyx^®)
• Nafcillin
• Nevirapine (Viramune^®)
• Oxcarbazepine (Trileptal^®)
• Pentobarbital (Nembutal^®)
• Phenobarbital (Luminal^®)
• Phenytoin (Dilantin^®, Phenytek^®)
• Primidone (Mysoline^®)
• Rifabutin (Mycobutin^®)
• Rifampin (Rifadin^®)
• Rifapentine (Priftin^®)
• St. John's wort

• CYP 3A4 inhibitor medications, such as:

• Amprenavir (Agenerase^®)
• Atazanavir (Reyataz^®)
• Clarithromycin (Biaxin^®)
• Conivaptan (Vaprisol^®)
• Darunavir (Prezista^®)
• Delavirdine (Rescriptor^®)
• Diltiazem (Cardizem^®, Cardizem CD^®, Cardizem LA^®, Cartia XT^®, Dilacor XR^®, Dilt-CD^®, Diltia XT^®, Dilt-XR^®, Taztia XT^®, Tiazac^®)
• Erythromycin
• Fosamprenavir (Lexiva^®)
• Imatinib (Gleevec^®)
• Indinavir (Crixivan^®)
• Isoniazid
• Itraconazole (Sporanox^®)
• Ketoconazole (Nizoral^®)
• Lopinavir and ritonavir (Kaletra^®)
• Miconazole
• Nefazodone (Serzone^®)
• Nelfinavir (Viracept^®)
• Nicardipine (Cardene^®)
• Posaconazole (Noxafil^®)
• Quinidine
• Ritonavir (Norvir^®)
• Saquinavir (Fortovase^®, Invirase^®)
• Telithromycin (Ketek^®)
• Voriconazole (VFEND^®)

• Medications that increase the risk of bleeding, such as:

• Antithrombin (ATryn^®, Thrombate III^®)
• Argatroban
• Aspirin (Bayer^® and others)
• Bivalirudin (Angiomax^®)
• Cilostazol (Pletal^®)
• Clopidogrel (Plavix^®)
• Dabigatran (Pradaxa^®)
• Dipyridamole (Persantine^®)
• Drotrecogin alfa (Xigris^®)
• Eptifibatide (Integrilin^®)
• Fondaparinux (Arixtra^®)
• Heparin or heparin-like products, including dalteparin (Fragmin^®), enoxaparin (Lovenox^®), or tinzaparin (Innohep^®)
• Lepirudin (Refludan^®)
• Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

• Celecoxib (Celebrex^®)
• Diclofenac (Cambia™, Cataflam^®, Flector^®, Pennsaid^®, Solaraze^® Gel, Voltaren^®, Voltaren^® Gel, Voltaren^®-XR, Voltaren Ophthalmic^®, Zipsor™)
• Etodolac (Lodine^®, Lodine^® XL)
• Ibuprofen (Motrin^®, Advil^®, Nuprin^®)
• Indomethacin (Indocin^®, Indocin SR^®)
• Ketoprofen (Orudis^®, Actron^®, Oruvail^®)
• Ketorolac (Sprix™, Toradol^®)
• Meloxicam (Mobic^®)
• Nabumetone (Relafen^®)
• Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
• Oxaprozin (Daypro^®)
• Piroxicam (Feldene^®)
• Others (see List of NSAIDs for a more complete list of these medications)

• Pentoxifylline (Trental^®)
• Prasugrel (Effient^®)
• Thrombolytics, such as:

• Alteplase (Activase^®)
• Reteplase (Retavase^®)
• Streptokinase (Streptase^®)
• Tenecteplase (TNKase^®)

• Ticlopidine (Ticlid^®)
• Tirofiban (Aggrastat^®)
• Ticagrelor (Brilinta™)
• Warfarin (Coumadin^®, Jantoven^®).