Trental and Pregnancy

In animal studies of Trental (pentoxifylline), the drug was shown to cause miscarriages when very high doses were given to pregnant rabbits. However, animals do not always respond to medicines in the same way that humans do, and a healthcare provider can still prescribe the drug if the benefits outweigh the risks.

Can Pregnant Women Take Trental?

Trental® (pentoxifylline) is a prescription medication approved to reduce the viscosity (thickness) of the blood and improve blood flow. Based on the results of animal studies, it may not be safe for pregnant women to take Trental.

What Is Pregnancy Category C?

The U.S. Food and Drug Administration (FDA) uses a pregnancy category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans, but do appear to cause harm to the fetus in animal studies.
Medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
In studies, giving high doses of Trental to pregnant rats and rabbits did not cause any birth defects in the offspring (even though the doses were high enough to cause problems in the mothers themselves). The very highest dosage used (which was equivalent to 24 times the recommended human dosage) caused miscarriages in rabbits.
However, it is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category C medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.

Final Thoughts

If you are pregnant or thinking about becoming pregnant, let your healthcare provider know. He or she will consider both the benefits and risks of taking this drug during pregnancy before making a Trental recommendation in your particular situation.
Pregnancy and Pain

Trental Medication Information

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