Trental Uses

How Does Trental Work?

Trental improves blood flow by increasing the ability of white and red blood cells to change shape as they pass through tight spaces, such as the narrowed blood vessels of peripheral arterial disease. The exact mechanism that allows this shape change is unknown.
Trental also reduces the viscosity (thickness) of the blood by reducing the activation and adhesion of neutrophils, the most common white blood cell. Neutrophils are first to respond to an injury, gathering at the site to protect it from infection. Activation and subsequent adhesion of the neutrophils at a site increases the viscosity (thickness) of the blood. Trental reduces this blood thickness so the blood flows more freely, allowing more oxygen to reach the extremities.

Can Children Use It?

This medication is not approved for use in children, as it has not been adequately studied in this age group. Talk with your child's healthcare provider about the benefits and risks of using this drug in children.

Off-Label Uses for Trental

On occasion, your healthcare provider may recommend Trental for something other than peripheral arterial disease (this would be known as an "off-label" use). Some possible off-label uses of Trental include the treatment of the following conditions:
  • Diabetic peripheral neuropathy
  • Diabetic atherosclerosis
  • Sickle cell disease
  • Gangrene
  • Clots in a hemodialysis shunt
  • Impotence (also known as erectile dysfunction, or ED) caused by poor blood flow
  • Malaria infections that have affected the brain
  • Septic shock
  • Vasculitis
  • Leg ulcers
  • Strokes
  • High altitude sickness
  • Eye and ear disorders.
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Trental Medication Information

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